Abstract
Biopharmaceutical Evaluation Of Oral Controlled Release Verapamil Hydrochloride Microcapsules
Biopharmaceutical behaviour of two controlled release microcapsule formulations of verapamil hydrochloride were described as evaluated in rabbit in comparison with drug material. Microcapsule formulation c coated with ethylcellulose and formulation j coated with Eudragit RS were also compared using pharmacokinetic parameters. Upon t test a significant difference between the formulations was observed in the parameters, K, T 1/2, AUC (o-α) MRT and bioavailability (F) but not in Vd, Cmax, Tmax and in all cases a highly significant difference was noted with drug material except in Vd. Wagner-Nelson method was employed for the assessment of in vivo sustained release absorption profiles of drug from the formulations. From the method of residuals, absorption lag time, absorption half life and absorption rate constant were estimated.
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