Abstract
Application of Urapidil Blood Pressure Regulation and Mechanical Ventilation Combined with Bone Window Craniotomy in the Treatment of Hypertensive Basal Ganglia Intracerebral Hemorrhage
Department of Neurosurgery, The First People’s Hospital of Wenling, Wenling, Zhejiang Province 317500, China
Correspondence Address:
Huihui Chen, Department of Neurosurgery, The First People’s Hospital of Wenling, Wenling, Zhejiang Province 317500, China, E-mail: duanhongyu@hdu.edu.cn
We attempts to study the application of urapidil blood pressure regulation and mechanical ventilation combined with bone window craniotomy in the treatment of hypertensive basal ganglia intracerebral hemorrhage. Retrospectively selected 98 patients with hypertensive basal ganglia intracerebral hemorrhage who underwent bone window craniotomy hematoma removal and decompression in our hospital from May 2018 to may 2021. Divided them into two groups with 49 cases in a single group. Treated control group with routine treatment combined with mechanical ventilation, after receiving the same treatment as control group, observation group received another urapidil for blood pressure regulation. Compared both groups in cerebral oxygen uptake rate, intracranial pressure, middle cerebral artery blood flow parameters, Glasgow Coma Scale score and 3 mo prognosis conditions. Compared with control group, the intracranial pressure in observation group was remarkably lower at 3 and 7 d after operation, the average velocity of middle cerebral artery at 7 d after operation was remarkably higher and the pulsatility index was remarkably lower than that in control group (p<0.05). 7 d after operation, both groups had higher Glasgow Coma Scale scores than before operation (p<0.05). Compared with control group, 7 d after operation, Glasgow Coma Scale score of observation group was significantly higher (p<0.05). 3 mo after operation, good recovery rate (24.49 %) and moderate disability rate (46.94 %) in observation group were higher than those in control group, but severe disability rate (12.24 %) and mortality rate (6.12 %) were lower than those in control group and the vegetative state rate (10.20 %) had no significant difference compared with control group (p>0.05). Urapidil blood pressure regulation and mechanical ventilation combined with bone window craniotomy in the treatment of hypertensive basal ganglia intracerebral hemorrhage can reduce cerebral oxygen uptake rate, regulate middle cerebral artery blood flow parameters and improve prognosis.
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