Abstract
Application of orange G dye for quantitation of citalopram hydrobromide, donepezil hydrochloride and rabeprazole sodium from tablet formulation
Department of Pharmaceutical Sciences, M. L. Sukhadia University, Udaipur-313 001, India
Correspondence Address:
I Singhvi Department of Pharmaceutical Sciences, M. L. Sukhadia University, Udaipur-313 001 India E-mail: indrajeet_s@yahoo.com
Three simple, rapid and accurate visible spectrophotometric methods have been developed using Orange G dye for the quantitative estimation of citalopram hydrobromide, donepezil hydrochloride and rabeprazole sodium from respective tablet formulations. These developed methods are based on formation of chloroform-extractable coloured complex of drug and dye. The extracted coloured complex shows absorption maxima at 476 nm and linearity in the concentration range of 10-50 μg/ml for citalopram hydrobromide (method I); at 482 nm and linearity in the concentration range of 5-35 μg/ml for donepezil hydrochloride (method II) and at 477.4 nm with linearity in the concentration range of 10-70 μg/ml for rabeprazole sodium (method III). The results of analysis for all three developed methods were validated statistically and by recovery studies.
