Abstract

To observe the application and effects of remifentanil in conjunction with sevoflurane in elderly total hip arthroplasty. The research participants in this retrospective study consisted of 95 elderly patients who underwent total hip arthroplasty at our hospital during the period from October 2022 to October 2023. They were randomly allocated into either the control group (48 cases) or the observation group (47 cases). Intravenous administration of etomidate infusion (0.2 mg/kg), midazolam injection (0.02 mg/kg), sufentanil citrate injection (0.5 μg/kg), and cisatracurium besylate injection (0.1 mg/kg) were incorporated into the anesthesia induction protocol for the control group. Subsequent to tracheal intubation and initiation of mechanical ventilation, a continuous intravenous infusion of propofol emulsion at a rate of 4-6 mg/kg/h and remifentanil hydrochloride injection at a rate of 0.2 μg/kg/min was administered. The anesthesia induction protocol for the observation group involved the administration of 5 % sevoflurane inhalation, intravenous infusion of cisatracurium besylate injection at a dose of 0.1 mg/kg, midazolam injection at a dose of 0.02 mg/kg, remifentanil hydrochloride injection at a dose of 1 μg/kg, and etomidate injection at a dose of 0.1 mg/kg. Subsequent to tracheal intubation and initiation of mechanical ventilation, the patients were administered inhalation of sevoflurane at a concentration range of 1 % to 1.5 %, along with a continuous intravenous infusion of propofol emulsion at a dosage of 3-6 mg/kg/h and remifentanil hydrochloride injection at a dosage of 0.1 μg/kg/min. There was no substantial difference in the incidence of adverse reactions between the two groups (p>0.05). The application of remifentanil in conjunction with sevoflurane in elderly total hip arthroplasty has several advantages. By employing this combination, healthcare providers can achieve reduced durations of loss of consciousness, extubation, and awakening in patients, ensuring a significant analgesic effect and promoting a desirable state of postoperative sedation. Importantly, this approach exemplifies a robust safety profile.