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Abstract
Antioxidant and antiinflammatory activities of the flowers of Tabernaemontana coronaria (l) R.BR
Author(s): Priya T Thambi, Bindu Kuzhivelil, MC Sabu, CI Jolly
Amala Cancer Research Centre, Amala Nagar, Thrissur-680 555, India
Correspondence Address:
C I Jolly Amala Cancer Research Centre, Amala Nagar, Thrissur-680 555, India E-mail: amalaresearch@rediffmail.com
Amala Cancer Research Centre, Amala Nagar, Thrissur-680 555, India
Correspondence Address:
C I Jolly Amala Cancer Research Centre, Amala Nagar, Thrissur-680 555, India E-mail: amalaresearch@rediffmail.com
The ethanol and aqueous extracts of Tabernaemontana coronaria flowers possessed significant in vitro superoxide, hydroxyl radicals, nitric oxide scavenging, and lipid peroxidation inhibiting activities. The antiinflammatory activity of the ethanol extract was evaluated by carrageenan-induced acute and formalin-induced chronic antiinflammatory models in mice. The extract showed remarkable antiinflammatory activity in both models, comparable to the standard reference drug diclofenac. The results suggest that the antiinflammatory activity of the ethanol extract of T. coronaria is possibly attributed to its free radical scavenging properties.
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