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Abstract
AntiHIV, antibacterial and antifungal activities of some novel 2-methyl-3-(substituted methylamino)-(3H)-quinazolin-4-ones
Author(s): V Alagarsamy1, S Murugesan1, K Dhanabal1, M Murugan1, E De Clercq2
1 Medicinal Chemistry R&D Laboratory, Arulmigu Kalasalingam College of Pharmacy, Anand Nagar, Krishnankoil - 626 190, India 2 Rega Institute for Medical Research, Minderbroederstrart - 10, Belgium, India
Correspondence Address:
V Alagarsamy Medicinal Chemistry R&D Laboratory, Arulmigu Kalasalingam College of Pharmacy, Anand Nagar, Krishnankoil - 626 190 India E-mail: samy_veera@yahoo.com
1 Medicinal Chemistry R&D Laboratory, Arulmigu Kalasalingam College of Pharmacy, Anand Nagar, Krishnankoil - 626 190, India 2 Rega Institute for Medical Research, Minderbroederstrart - 10, Belgium, India
Correspondence Address:
V Alagarsamy Medicinal Chemistry R&D Laboratory, Arulmigu Kalasalingam College of Pharmacy, Anand Nagar, Krishnankoil - 626 190 India E-mail: samy_veera@yahoo.com
The title compounds 2-methyl-3-(substituted methylamino)-(3 H )-quinazolin-4-ones were synthesized by condensing the active hydrogen atom of the amino group of 3-amino-2-methyl-(3 H )-quinazolin-4-one with formaldehyde and appropriate amines. Their structures were confirmed by spectral data (IR, 1H-NMR and Mass) and the purity was ascertained by elemental analysis. Investigation of antimicrobial activity of the test compounds was performed by agar dilution method against 7 pathogenic bacteria, 3 pathogenic fungi and antiHIV activity against replication of HIV-1(IIIB) and HIV-2 (ROD) in MT-4 cells. The compounds exhibited significant antibacterial and antifungal activities.
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