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Abstract
Anti-HIV Activity Of Some Mannich Bases Of Isatin Derivatives
Author(s): S. N Pandeya, D Sriram, E De. Clercq, Christophe Pannecouque, Myriam Witvrouw
A number of Mannich bases of Isatin were synthesised and screened for anti-HIV activity. The Schiff’s base derived from 5-Methylisatin and trimethoprim was converted into Mannich bases. The N-dimethyl (Pan I) and morpholino (Pan M) were the most active compounds in the series and gave maximum protection against HIV-1 (III B) strain.
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