Abstract

The well-known plant components for their anti-diabetic properties are Azadirachta indica leaves, Pterocarpus marsupium heartwood, Picrorhiza kurroa rhizomes and Withania coagulans berries and fruit coat. The current study's objective was to create a polyherbal dosage form and assess its effectiveness and stability. The various methanolic extracts of all four medicines were combined in the 1:1:1:1 ratios to create the polyherbal extract. Both in vitro antioxidant and in vitro antidiabetic activity of the extract were evaluated. For their preformulation investigations, a total of six polyherbal compositions were examined. Through Fourier transform infrared spectroscopic analysis, the phytochemicals present were identified. The medication was then put into capsules with a 0 size and evaluated for every aspect of a capsule. The stability of the most recent medicine was examined under diverse circumstances. The 2,2-diphenyl-1- picrylhydrazyl half maximal inhibitory concentration value for the polyherbal extract was 60.56 μg/ml indicating in vitro antioxidant activity. The anti-diabetic action was equivalent to the industry standard and dose-dependent, with an half maximal inhibitory concentration value of 59.82 μg/ml for inhibiting alpha-amylase and 67.28 μg/ml for inhibiting alpha-glucosidase. The polyherbal formulation 1 displayed the best flow qualities. According to Fourier transform infrared spectroscopic data, granules may include terpenes, tannins, phenols and flavonoids. In 30 min, the capsules with polyherbal formulation 1 had a 95.77 % cumulative drug release value. The capsules were discovered to be stable under many types of lighting, however they disintegrate above 70 % humidity and over 55°. As a result, it was discovered that the polyherbal capsules were stable and effective in treating hyperglycemia.