Abstract

To investigate the characteristics and influencing factors of electrocardiogram changes in patients with thyroid cancer after operation. This study retrospectively analyzed the case data of 122 patients who underwent thyroid surgery for the first time in the department of breast and thyroid surgery from January 2020 to December 2021. All patients were pathologically confirmed to be papillary thyroid carcinoma. Firstly, the perioperative changes of electrocardiogram indexes were compared in all patients and then the influencing factors (age, sex, blood lipid level, body mass index and surgical method) of perioperative electrocardiogram changes were analyzed by univariate analysis. After operation, the serum thyroid stimulating hormone of all patients was higher and serum free triiodothyronine and free thyroxine were lower than that before operation (p<0.05). After operation, PR interval and QRS duration was shorter than before operation (p<0.05). The perioperative changes of heart rate were statistically significant in different age groups (p=0.043). The age group ≥55 y old had more obvious heart rate changes than the age group <55 y old. There was a difference in heart rate change between groups in different body mass index group (p=0.05). Perioperative free triiodothyronine was positively correlated with heart rate (r=0.476, p=0.004). The change of perioperative free thyroxine was negatively correlated with the change of PR interval duration (r=-0.411, p=0.016). The difference of perioperative corrected QT interval between male and female was statistically significant (p=0.027). There was a negative correlation between perioperative free thyroxine change and p wave change (r=-0.416, p=0.014). Age, gender and body mass index have a certain influence on the changes of perioperative electrocardiogram indicators. Postoperative cardiac function monitoring should be strengthened in elderly and obese patients. The change of thyroid hormone level is correlated with the change of perioperative electrocardiogram index. In the process of long-term thyroid stimulating hormone suppression treatment after operation, it can be tried to establish the sex-age related electrocardiogram standard of stratified thyroid hormone level.