Abstract
Aloe vera Nanoparticles Loaded with Antihypertensive Beta-Blockers of Different Half-Life: Entrapment Efficiency and Release Behavior
School of Studies in Chemistry and Biochemistry, Vikram University, Ujjain, Madhya Pradesh 456010, 1Parul Institute of Applied Sciences, Parul University, Vadodara, Gujarat 391760, 2Department of Pharmacy, Industrial Pharmacy Research Lab, Shri G. S. Institute of Technology and Science, Indore, Madhya Pradesh 452003, India
Correspondence Address:
Rachana Sharma, Parul Institute of Applied Sciences, Parul University, Vadodara, Gujarat 391760, India, E-mail: sharmarachana385@gmail.com
Biopolymeric nanocarriers have become potential candidates for drug delivery applications due to outstanding virtues such as biodegradability, biocompatibility, low toxicity and low cost. The present study involves the synthesis of such biopolymeric nanocarriers prepared from Aloe vera gel, conjugated with antihypertensive model drugs (atenolol, bisoprolol and propranolol) using ionotropic gelationpolyelectrolyte complexation and the determination of entrapment efficiencies, in vitro release of these drugs from nanoparticles followed by the study of release kinetics. The synthesized antihypertensive drug-loaded nanoparticles were undertaken for characterization using Ultraviolet-Visible spectroscopy, Scanning Electron Microscopy, Fourier Transform Infra-red Spectroscopy and Zeta potential measurements and Powder X-ray diffraction analysis. The analysis ended up with confirmation of the semi-crystalline nature of the synthesized drug-loaded nanoparticles with an average size of 86.97±2.17 nm, 78.32±1.97 nm and 89.36±2.15 nm for atenolol, bisoprolol and propranolol loaded Aloe vera (gel) nanoparticles respectively determined with X-ray diffraction analysis. AGATEBC NPs, AGBISBC NPs, and AGPROBC NPs followed Korsmeyer-Peppa’s model for drug release with Anomalous (non-Fickian) transport.
