Abstract
Advances in the Pathogenesis of Oral Submucosal Fibrosis and Animal Models
Department of Stomatology, First Affiliated Hospital of Hainan Medical University, Haikou 570102, 1School of Stomatology, Hainan Medical University, Haikou 571199, 2Key Laboratory of Tropical Biological Resources of Ministry of Education, and Hainan Engineering Research Centre for Drug Screening and Evaluation, Haikou 570228, 3Department of Stomatology, The People's Hospital of Longhua, Shenzhen 518109, China
Correspondence Address:
Hai Bin Luo, Key Laboratory of Tropical Biological Resources of Ministry of Education, and Hainan Engineering Research Centre for Drug Screening and Evaluation, Haikou 570228, China, E-mail: hbluo@hainanu.edu.cn
Oral submucous fibrosis is a common precancerous state, which is characterized by abnormal collagen deposition, epithelial atrophy and microvascular disease. There are many factors that may contribute to the development of the pathogenesis, including environmental factors, genetic predisposition, and immune system abnormalities. About 7 %-13 % of oral submucous fibrosis cases can transform into malignant tumors. Therefore, how to establish an animal model with the same pathological mechanism as human oral submucous fibrosis is an urgent problem to be solved. For animal models, researchers have successfully established various animal models of oral submucous fibrosis by transplanting human oral mucosal tissue or inducing the condition with specific drugs. These models provide a powerful tool for studying the pathogenesis and treatment of oral submucous fibrosis. Consequently, this paper summarized the pathogenesis of oral submucous fibrosis and six methods of constructing the oral submucous fibrosis animal models, so as to identify new drug targets for the development of anti-oral submucous fibrosis drugs, lay a theoretical foundation and provide new treatment thinking for clinical work.
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