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Abstract
A Validated High Performance Thin Layer Chromatographic Determination Of Fenofibrate
Author(s): K. R Gupta, S. B Wankhede, S. G Wadodkar
The present work describes a validated high performance thin layer chromatographic method for estimation of fenofibrate in capsules. Aluminum plates precoated with Silica gel 60 F254 was used as stationary phase and toluene: chloroform (7:3 v/v) as mobile phase. Quantification was carried out by the use of densitometric absorbance mode at 296 nm. The amount of fenofibrate estimated as percentage of labeled claimed was found to be 101.43/100.68 (as per the peak height and peak area) in capsules. The proposed high performance thin layer chromatographic method was quantitatively evaluated in terms of stability, precision, repeatability and accuracy. The calibration correlation proving, it's utility for routine analysis of fenofibrate capsule.
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