Abstract
A Network Pharmacology Study on the Mechanism of Atorvastatin in the Treatment of Chronic Subdural Hematoma
Department of Neurosurgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China, 1Division of Medical Physics, Department of Diagnostic and Interventional Radiology, University Medical Center Freiburg, University of Freiburg, Freiburg 79108, Germany, 2Department of Aviation Psychology Research, Xi’an Civil Aviation Hospital, Xi’an 710082, 3Department of Ophthalmology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China
Correspondence Address:
Ting Wei, Department of Ophthalmology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China, E-mail: liangchen01@xjtu.edu.cn
Chronic subdural hematoma primarily affects the elderly, and its morbidity increases with the global rise in the elderly population. Atorvastatin, commonly prescribed for hypercholesterolemia and atherosclerosis, has shown therapeutic promise for chronic subdural hematoma, although its mechanism remains unclear. This study employs network pharmacology and reverse transcription-quantitative polymerase chain reaction to analyze and preliminarily verify atorvastatin's potential mechanism in treating chronic subdural hematoma. Analysis identified 19 potential targets of atorvastatin in chronic subdural hematoma treatment. Enrichment analysis revealed that these target genes predominantly regulate inflammation, angiogenesis, and coagulation/fibrinolysis. From the 19 target genes, matrix metalloproteinase 2, matrix metalloproteinase 9, interleukin-6, C-X-C motif chemokine ligand 8, and serpin family E member 1 were selected to verify atorvastatin's effect. Reverse transcription-quantitative polymerase chain reaction demonstrated that atorvastatin significantly suppressed the expression of these genes in human umbilical vein endothelial cells (p<0.01). These findings partially elucidate atorvastatin's potential mechanism in treating chronic subdural hematoma, offering research insights and a foundation for further study.
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