Abstract
A Comparative Dissolution Study Of Commercial And Prepared Formulations Of Celecoxib
Celecoxib, a COX-2 inhibitor, useful in the relief of symptoms of rheumatoid arthritis, suffers from the draw back of poor aqueous solubility, thereby giving problems during formulations and in achieving good oral bioavailability. The present paper attempts at preparing three formulations of celecoxib in conjunction with β-cyclodextrin for the purpose of solubility enhancement of the drug. The formulations were tested in different media (water, 0.1 N HCI, phosphate buffer pH 7.4). Phosphate buffer was found to be the most suitable amongst the three with good discriminating power. The formulations were compared with two marketed capsule samples of celecoxib. A marked enhancement in the dissolution of celecoxib from the laboratory made formulations was observed as compared to the marketed preparations.
